CBIO-30DISRUPTED OLIGODENDROCYTE PRECURSOR CELL ASYMMETRIC DIVISION GENERATES PHENOTYPES REMINISCENT OF NEOPLASTIC TRANSFORMATION
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چکیده
منابع مشابه
Asymmetric cell division in normal and malignant hematopoietic precursor cells.
Every second of our lives, millions of blood cells are destroyed and must be regenerated. This regeneration is accomplished by hematopoietic stem cells (HSCs), the only cells that throughout life are able to both produce the required new cells of all blood lineages and maintain their own numbers. Obviously, the regulation of HSC fate decisions between remaining in the stem cell state (selfrenew...
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C. elegans, with its invariant cell lineage, provides a powerful model system in which to study signaling-dependent asymmetric cell division. The C. elegans β-catenin-related protein, WRM-1, specifies endoderm at the 4-cell stage during the first cell signaling-induced asymmetric cell division of embryogenesis. During this interaction, Wnt signaling and the cell cycle regulator CDK-1 act togeth...
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Address correspondence to Mark Noble, Huntsman Cancer Institute, Rm. 4280, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112. Tel.: (801) 585-7167. Fax: (801) 585-7120. E-mail: [email protected] The physiological demands made upon precursor cell populations during different developmental epochs can be remarkably divergent, particularly in tissues that do not...
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Stem cells self-renew but also give rise to daughter cells that are committed to lineage-specific differentiation. To achieve this remarkable task, they can undergo an intrinsically asymmetric cell division whereby they segregate cell fate determinants into only one of the two daughter cells. Alternatively, they can orient their division plane so that only one of the two daughter cells maintain...
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Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell division in the nematode Caenorhabditis elegans is mediated by a pathway invol...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2015
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nov209.30